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MORE | Juul to pay $462 million to six states in e-cigarette maker's largest settlement ever Since then, the FDA said Thursday it has "conducted additional substantive review of the applications in a number of disciplines, including toxicology, engineering, social science, and clinical pharmacology." The reversal is based on a "review of information provided by the applicant" as well as new case law stemming from court decisions involving marketing denial orders, or MDOs, for e-cigarette products, the FDA said